Title#
Disrupted Brain Connectivity Networks in Drug-Naive, First-Episode Major Depressive Disorder
Results#
- MDD患者表现出了全局属性的改变：更短的最短路径长度和更高的全局效率→朝着随机网络转变；
- 尾状核和默认网络脑区中心性在MDD组中增加；
- 枕叶、眶额和颞叶脑区中心性下降；
Conclustions#
- MDD is associated with disruptions in the topological organization of functional brain networks;
- Disruption in the topological organization may contribute to disturbances in mood and cognition in MDD;
Notes#
- 网络稀疏性选择标准：(1) 网络平局度>2*log(N)，N为网络节点数；(2) 小世界属性大于1.1；
- AUC指标提供了独立与单个稀疏性下的综合度量，summaried scale;
- NBS, Network-based statistic, 对网络中的连边进行统计的方法；
- Nonparametric permutation test;
- Combination of high local clustering and short path length supports the two fundamental organizational principles in the brain: functional segregation and functional integration;