Title#
Segregated systems of human brain networks
Notes#
RSFC within and between brain system exhibits progressive difference across adulthood, even in the absence of disease.
Increasing age is associated with decreasing connectivity within systems and increasing connectivity between brain systems.
- increasing age is accompanied by decreasing segregation
- different types of functional systems exhibit different trajectories of age-related differences in system segregation
With healthy adult , increasing segregation is associated with superior cognitive ability independently of influence of age.
Higher RSFC segregation exhibit the greatest improvements, and positivity correlate with improvement in the therapy.
\(Segregation=(within-between)/within\)
Modularity is calculated as the fraction of edges that fall within the given communities of a network compared to the expected fraction if the connections were distributed at random across the network.
Future#
System segregation of an individual change over time and relation to their health
How do properties of the anatomical network of brain relate to the maintenance and modulation in segregation and integration of the brain network’s functional systems?
Mechanisms of dynamically adjust the segregation and integration
Optimal network regime or configuration, in aging and disease the differences in segregation
Individual differences
Reference#
Wig, G. S. . (2017). Segregated systems of human brain networks. Trends in Cognitive Sciences, 21(12), 981-996.